Buy Metaglip (Glipizide, Metformin Hydrochloride) antidiabetic medication
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METAGLIP (GLIPIZIDE, METFORMIN HCL) TABLETS: PRESCRIBING INFORMATION
Metaglip (Glipizide and Metformin HCl) tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes, glipizide and metformin hydrochloride.
Glipizide is an oral antihyperglycemic drug of the sulfonylurea class. The chemical name for glipizide is 1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea.
Glipizide is a whitish, odorless powder with a molecular formula of C21H27N5O4S, a molecular weight of 445.55 and a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide.
Metformin Hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or alpha-glucosidase inhibitors. It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.
Metaglip is available for oral administration in tablets containing 2.5 mg glipizide with 250 mg metformin hydrochloride, 2.5 mg glipizide with 500 mg metformin hydrochloride, and 5 mg glipizide with 500 mg metformin hydrochloride. In addition, each tablet contains the following inactive ingredients: povidone, microcrystalline cellulose, croscarmellose sodium, magnesium stearate. The tablets are film coated, which provides color differentiation.
Mechanism of Action
Metaglip combines glipizide and metformin hydrochloride, 2 antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with type 2 diabetes.
Glipizide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. Extrapancreatic effects may play a part in the mechanism of action of oral sulfonylurea hypoglycemic drugs. The mechanism by which glipizide lowers blood glucose during longterm administration has not been clearly established. In man, stimulation of insulin secretion by glipizide in response to a meal is undoubtedly of major importance. Fasting insulin levels are not elevated even on long-term glipizide administration, but the postprandial insulin response
continues to be enhanced after at least 6 months of treatment.
Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
PHARMACOKINETICS IN SPECIAL POPULATIONS
Metaglip pharmacokinetics in special populations
Metaglip clinical studies
INDICATIONS AND USAGE
Metaglip (Glipizide and Metformin HCl) tablets is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Metaglip special warning
PRECAUTIONS FOR METFORMIN HYDROCHLORIDE
Metaglip precautions for metformin hydrochloride
Metaglip drug interactions
Metaglip nonclinical toxicology
USE IN PREGNANCY
Metaglip use in pregnancy
USE IN SPECIFIC POPULATIONS
Metaglip use in specific populations
Metaglip adverse reactions
DOSAGE AND ADMINISTRATION
Metaglip dosage and administration
Metaglip 2.5 mg / 250 mg tablet is a pink oval-shaped, biconvex film-coated tablet with "BMS" debossed on one side and "6081" debossed on the opposite side, in bottles of 100 tablets.
Metaglip 2.5 mg / 500 mg tablet is a white oval-shaped, biconvex film-coated tablet with "BMS" debossed on one side and "6077" debossed on the opposite side, in bottles of 100 tablets.
Metaglip 5 mg / 500 mg tablet is a pink oval-shaped, biconvex film-coated tablet with "BMS" debossed on one side and "6078" debossed on the opposite side, in bottles of 100 tablets.
Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F). [See USP Controlled Room Temperature.]
Manufactured and distributed by Merck, Bristol-Myers Squibb pharmaceutical companies and their divisions.
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