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METAGLIP (GLIPIZIDE, METFORMIN HCL) TABLETS: INFORMATION FOR PATIENTS

Metaglip

Patients should be informed of the potential risks and benefits of Metaglip (Glipizide with Metformin Hydrochloride) tablets and alternative modes of therapy. They should also be informed about the importance of adherence to dietary instructions; a regular exercise program; and regular testing of blood glucose, glycosylated hemoglobin, renal function, and hematologic parameters.

The risks of lactic acidosis associated with metformin therapy, its symptoms, and conditions that predispose to its development, as noted in the "Warnings" and "Precautions" sections, should be explained to patients. Patients should be advised to discontinue Metaglip immediately and promptly notify their health practitioner if unexplained hyperventilation, malaise, myalgia, unusual somnolence, or other nonspecific symptoms occur.

Once a patient is stabilized on any dose level of Metaglip (Glipizide and Metformin), gastrointestinal symptoms, which are common during initiation of metformin therapy, are unlikely to be drug related. Later occurrence of gastrointestinal symptoms could be due to lactic acidosis or other serious disease.

The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members.

Patients should be counseled against excessive alcohol intake, either acute or chronic, while receiving Metaglip.

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